What problem occurs when removal of material from the tablet's surface by punches requires lubricant adjustment?

What problem occurs when removal of material from the tablet's surface by punches requires lubricant adjustment?

• A. Capping
• B. Picking/sticking
• C. Laminating
• D. Whiskering

Answer: (B)

When removal of material from the tablet's surface by punches requires lubricant adjustment, it indicates an issue with adherence of the tablet material to the punches during compression. This problem is referred to as picking or sticking. Picking occurs when the tablet material adheres to the punches during the tablet formation process, which can lead to incomplete tablets or defects in the tablet's surface. Sticking, which is closely related, refers to the material sticking to the facing surfaces of the equipment, causing issues in the ejection phase of tablet production. Adjusting the lubricant can help alleviate these issues by reducing friction between the tablet material and the punches, thus promoting a better flow and manufacturing process. The other choices represent different problems encountered in tablet formulation and manufacturing: capping refers to the separation of the top or bottom of a tablet, laminating is the formation of layers within a tablet, and whiskering describes the formation of fine "whiskers" on the surface of tablets, often due to excess moisture or improper mixing. These terms reflect distinct issues that do not directly relate to the adjustment of lubricants for material removal.

When removal of material from the tablet's surface by punches requires lubricant adjustment, it indicates an issue with adherence of the tablet material to the punches during compression. This problem is referred to as picking or sticking.

Picking occurs when the tablet material adheres to the punches during the tablet formation process, which can lead to incomplete tablets or defects in the tablet's surface. Sticking, which is closely related, refers to the material sticking to the facing surfaces of the equipment, causing issues in the ejection phase of tablet production. Adjusting the lubricant can help alleviate these issues by reducing friction between the tablet material and the punches, thus promoting a better flow and manufacturing process.

The other choices represent different problems encountered in tablet formulation and manufacturing: capping refers to the separation of the top or bottom of a tablet, laminating is the formation of layers within a tablet, and whiskering describes the formation of fine "whiskers" on the surface of tablets, often due to excess moisture or improper mixing. These terms reflect distinct issues that do not directly relate to the adjustment of lubricants for material removal.